PRECLINICAL STUDIES COMPARING EFFICACY AND TOXICITY OF DNA REPAIR INHIBITORS, OLAPARIB, AND ASIDNA, IN THE TREATMENT OF CARBOPLATIN-RESISTANT TUMORS

Preclinical Studies Comparing Efficacy and Toxicity of DNA Repair Inhibitors, Olaparib, and AsiDNA, in the Treatment of Carboplatin-Resistant Tumors

Purpose: Carboplatin is used to treat many cancers, but occurrence of drug resistance and its high toxicity remain a clinical hurdle limiting its efficacy.We compared the efficacy and toxicity of DNA repair inhibitors olaparib or AsiDNA administered alone or in combination with carboplatin.Olaparib acts by inhibiting PARP-dependent repair pathways

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Mini-Open Double-row Subscapularis Repair with Biceps Tenodesis for a Missed Lafosse Type 3 Subscapularis Tear with Biceps Subluxation: A Case Report

The accuracy of diagnosing full-thickness Subscapularis (SSC) tendon tears depends on the presence or absence of Long Head of Biceps Tendon (LHBT) and subluxation is 30x24x24 wall cabinet quite variable.This case report outlines a middle aged man with symptomatic medial dislocation of the long head of the biceps with associated rotator cuff injury.

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Eskatologie in die boek Sefanja

Eschatology in Zephaniah That the hook Zephaniah is of an eschatological nature, is posed as a hypothesis.This means that the judgement and salvation themes in the hook occur in such a relationship that it can he described as eschatology.Judgement in Zephaniah has the characteristics of a radical and peperomia double duty final judgement with which

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